I did an interview with American Airlines pilot Kent Wien back in August of 2011 and Kent talked about the process of getting approval to replace their bulky paper manuals and documentation with iPads.
Kent says, "The long awaited, previously announced iPad Electronic Flight Bag (EFB) has finally been approved for most of our airplanes at the company." http://www.gadling.com/2013/03/20/cockpit-chronicles-the-ipad-flight-bag-is-finally-here-video/
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